Vol 7, No 1 (2011)
Articles
19-28 605
Abstract
Review of the literature devoted to the actual problem that has been raised in connection with the widespread use of preparations of interferon in the treatment of various diseases. It is obvious that the thyroid function disorders often develop as the result of interferon therapy. This review presents the recent data on prevalence, clinical presentation and course, as well as the principles of treatment of interferon-induced thyroid disorders.
36-40 495
Abstract
According to the data of the register, a high frequency of arrest of physical and mental development, functional alterations of cardiovascular system, anemia, dislipidemia, subcompensated conditions of thyroid function among children younger than 18 years were revealed. Organization of neonatal screening for congenital hypothyroidism in Smolensk region made it possible to reach a high percent of newborn's investigation, coverage of re-test, reduction of investigation terms and start of treatment. At the same time results of neonatal screening have shown insufficient iodine supply of pregnant women and necessity of strengthened control of iodine prevention during pregnancy.
41-44 908
Abstract
Our purpose was to investigate the short-term influence of thyroxin replacement therapy on arterial hypertension (AH) and heart remodeling in patients with primary hypothyroidism (PH). 52 patients with PH and AH received basic antihypertensive therapy unchanged during the period of study and individual l-thyroxin titration. All patients underwent echocardiography and daily blood pressure monitoring twice: in decompensation and after reaching euthyroid state in 3–4 months. Decrease in systolic blood pressure daytime by 5.6% (p<0.01), nighttime by 4.3% (p<0.05), left atrium volume by 12.8% (р<0.05), interventricular septum thickness by 5.8% (p<0.05), posterior wall thickness by 5.4% (p<0.05), end-diastolic dimension by 3.1% (p<0.05) and left ventricular mass index by8.1% (р<0.05) were observed in the patients with PH after reaching euthyroid state. Compensation of thyroid state in patients with PH and AH leads to decrease in systolic BP and improvement of echocardiographic left ventricular parameters.
45-49 436
Abstract
The aim of this study was to investigate the usefulness of immunohistochemical expression galectin-3 for differential diagnosis follicular carcinoma and follicular adenoma in a sample of thyroid lesions using a specific antigalectin-3 monoclonal antibody. We evaluated 36 thyroid lesions including 15 follicular carcinomas, 15 follicular adenomas, and in 6 cases there was a combination of follicular carcinomas and follicular adenomas. Galectin-3 expression was detected in 8 of 15 (53.3%) follicular adenomas, 13 of 15 (86.7%) follicular carcinomas and in 6 of6 (100%) combined cases. The sensitivity, specificity, efficiency and diagnostic accuracy of this test method were73.6%, 81.8%, 77.7% and 77%, respectively. Galectin-3 expression determined in 53.3% of adenomas. The average level of the expression in adenoma cells was significantly lower compared with carcinoma. Galectin-3 can’t be used for differential immunohistochemical diagnosis of follicular thyroid tumors because the expression of the marker in cells of follicular carcinoma was only 86.7%. Expression of galectin-3 in the cells of adenomas with a combination of follicular adenoma and follicular cancer was revealed in all cases. In the adenoma tissue mean expression level was significantly lower than in carcinoma. So galectin-3 can’t be used as the sole marker but definition of the expression galectin-3 may be important in the complex diagnosis follicular thyroid tumors and also in combination with other markers. The expression of galectin-3 chance of having a malignant nature of the tumor was significantly higher.
50-54 403
Abstract
The long-term results of subtotal resection of thyroid gland on 82 patients with Graves' disease were studied. There was analysed the influence of three factors on outcome at Graves' disease: volume of a thyroid gland before operation, morphological structure of thyroid tissue and volume of thyroid remnant. Outcomes of subtotal resection of thyroid gland were studied on the basis of thyrotropic hormone level of blood in 3, 6, 12 months, 2 and 3 years after operation. Based on research it has been established that the volume of thyroid gland before operation does not influence to outcome of subtotal resection of thyroid gland with Graves' disease. Morphological changes of removed thyroid tissue in the form of colloidal nodules at patients with Graves' disease statistically significantly raise risk of development of postoperative complications after subtotal resection of thyroid gland. The surgeon defining the volume of thyroid rem-nant durng the operation could be mistaken as towards it's increase so towards it's reduction, with an average deviation about 35%. Various outcomes of subtotal resection of thyroid gland at the same volume of thyroid remnant let us conclude that this out-come depends more on intensity of autoimmune process rather than on the volume of thyroid remnant. According modern views to aetiology and patogenesis of Graves' disease, the optimum volume of operation at Graves' disease is thyroidectomy.
55-57 664
Abstract
Тo investigate circadian rhythm of TSH secretion during TSH-suppression therapy. 17 patients taking TSH-suppression therapy, at the age of 18–60 years have been included. Measurements of serum TSH were performed at8.00–9.00h and 14.00–16.00 during the day. The median of TSH concentrations in the morning was 0,016mU/l, at the daytime – 0.015mU/l. The amplitude of TSH circadian variability reached 200% (Me – 19%). At boundary TSH value stability of TSH-suppression can be broken. As specifying action research in similar situations can be measurement of serum TSH in other time.
58-62 459
Abstract
The article provides a description of congenital hypothyroidism and goiter in a newborn baby.
ISSN 1995-5472 (Print)
ISSN 2310-3787 (Online)
ISSN 2310-3787 (Online)