The cardiovascular signs and symptoms of thyroid disease are some of the most clinically relevant findings that accompany both hyperthyroidism and hypothyroidism. On the basis of the understanding of the mechanisms of thyroid hormone action on the heart and cardiovascular system, it is possible to explain the changes in cardiac output, cardiac contractility, blood pressure and rhythm disturbances that result from thyroid dysfunction. In the present review will integrate what is known about the mechanisms of thyroid hormone action on the heart and the alterations in thyroid hormone metabolism that accompany chronic congestive heart failure.

The aim of this study was estimate the influence of Iron Deficiency Anemia (IDA) on efficiency of the iodine prophylaxis for pregnant women, and also to offer the optimal levels of daily iodine intake during pregnancy and lactation. Materials and methods: serum thyroid stimulating hormone (TSH), free thyroxin (fT4), AT-TPO concentrations, urine excretion of iodine, levels of hemoglobin (Hb), hematocrit (Ht), red blood cell (RBC), mean corpuscular hemoglobin (MCH), serum iron levels and serum ferritin were measured. The volume of thyroid gland was defined by ultrasonography. The pregnant women were divided into two groups: Group 1 (n = 111) – KI (200 micro# grams/day) and Group 2 (n = 109) – KI (300 micrograms/day). Results: Median urinary iodine was 140,8 μg/l. During pregnancy there was an authentic rising of a median urinary iodine to 259,6 μg/l in group 2 (p = 0,0000) and in group 1 the iodine excretion in urine was more low than at a stage of screening and has compounded 96,9 μg/l (p = 0,002). During lactation there was an insufficient concentration of iodide in urine in group 1 and in group 2 there were normal indexes of a median urinary iodine – 88,6 and 123,2μg/l in groups 1st and 2nd accordingly (p = 0,004). In the third trimester 21,5% of women had a latent deficiency of iron. Authentic correlation between indexes of an iron deficiency anemia and iodine deficiency has not been detected. Conclusion: The median level of urinary iodine indicate optimal iodine nutrition during pregnancy and lactation and the requirement of iodine is at least 300 μg/day. In our research the negative influence of iron deficiency anemia on the efficiency of iodine prophylaxis during pregnancy has not been detected.

The purpose of our study was to investigate the main parameters of thyroid status in patients with rheumatoid arthritis (RA), as well as particularities of course of this disease depending on of thyroid gland function disorder. Materials and methods. 52 women with RA were examined. The first group consisted of 11 women with subclinical and manifestive hypothyroidism the second one 41 women without thyroid gland function disorder. The group comparison was conducted on main indexes of thyroid gland condition the hormon level, AT-TPO, ultrasonic data, as well as clinical and laboratory RA data. Results. In women with hypothyroidism the systemic manifestations of RA were more often truely diagnosed; DAS28 indexes, ESR, the number ot swollen joints were higher. The high level ot AT-TPO was diagnosed in 54,55% – I group and in 31,7% – II group TTG level was really less in patients receiving synthetic glycocorticoids. Small thyroid gland volume was diagnosed in 23,07% of examined patients. The thyroid gland status indexes in them did not differ from patients with normal thyroid gland volume. Reliable increasing of the peripheral resistance index was revealed in lower thyroid artery according to the ultrasonic study data under the reduced thyroid gland size. Conclusions. High incidence of hypothyroidism and AT-TPO carriage in RA was revealed. Hypothyroidism development is accompanied by high clinic-laboratory RA activity. The reduction of the thyroid gland volumes in RA is possibly stipulated not only by autoimmunal pathology, but also chronic ischemia of the organ in the conditions of immune-complex vasculitis and early atherosclerosis. The TTG level in patients with RA is defined not only by pathology of the thyroid gland, but glycocorticoid therapy as well.