Предикторы послеоперационного гипопаратиреоза после тиреоидэктомии и методы его лечения
Аннотация
Об авторах
N S Kuznetsovпрофессор, доктор мед. наук, заведующий хирургическим отделением ФГБУ Эндокриноло- гический научный центр
O V Simakina
аспирант хирургического отделения ФГБУ Эндокринологический научный центр
I V Kim
канд. мед. наук, старший научный сотрудник ФГБУ Эндокринологический науч- ный центр
Список литературы
1. Дедов И.И., Мельниченко Г.А. Эндокринология: национальное руководство. М.: ГЭОТАР-Медиа, 2008. 767–773.
2. Зенкова А.В. Состояние функции околощитовидных желез до и после хирургического лечения заболеваний щитовидной железы. Вестн. ОГУ 2010; 6: 74–77.
3. Зографски С. Эндокринная хирургия. София: Медицина и физкультура, 1977.
4. Попов О.С., Лян Н.И., Ларионов М.М. и др. Послеоперационный гипопаратиреоз и новый способ его профилактики. Вестн. ЮУрГУ 2010; 24: 88–90.
5. Попов О.С., Логвинов С.В., Лян Н.И. и др. Аутотрансплантация околощитовидных желез в профилактике послеоперацион- ного гипопаратиреоза. Бюллетень сиб. мед. 2011; 3: 125–128.
6. Романчишен А.Ф., Багатурия Г.О., Зенкова А.В. Профилактика гипопаратиреоза после операций на щитовидной железе. Вестн. хир. им. И.И. Грекова 2010; 2: 39–41.
7. Савенок Э.В. Послеоперационный гипопаратиреоз у больных раком щитовидной железы и его консервативное лечение. Системный анализ и управление в биомедицинских системах 2011; 4: 900–903.
8. Смирнов А.В., Эмануэль В.Л., Волков М.М., Каюков И.Г. Гомеостаз кальция и фосфора: норма и патология. Клин-лаб. консилиум. 2010; 5: 32–43.
9. Третьяк С.И., Хрыщанович В.Я., Горанов В.А., Романович А.В. Послеоперационный гипопаратиреоз после радикальных операций на щитовидной железе – пути решения проблемы. Мед. журн. 2007; 1: 87–89.
10. Хрыщанович В.Я., Третьяк С.И., Мохорт Т.В., Багомазова Е.В. Ретроспективный анализ результатов хирургических вмешательств на щитовидной железе. Онкол. журн. 2010; 4: 64–70.
11. Хрыщанович В.Я., Третьяк С.И. Проблемы заместительной терапии послеоперационного гипотиреоза. Вестн. ВГМУ 2011; 1: 89–98.
12. Чернышев В.А., Хамидуллин Р.Г., Зинченко С.В., Рудык А.Н. Центральная лимфодиссекция при первичном раке щитовидной железы. Сиб. онкол. журн. 2008; 6: 25–29.
13. Adam T.G., Miller F.R., Roehm C.E., Prihoda T.J. Predicting hypocalcemia after total thyroidectomy: Parathyroid hormone level vs. serial calcium levels. Ear, Nose & Throat J. 2010; 1. (http://readperiodicals.com/201009/2150894761.html#b)
14. Alia P., Moreno P., Rigo R. et al. Postresection Parathyroid Hormone and Parathyroid Hormone Decline Accurately Predict Hypocalcemia After Thyroidectomy.Am. J. Clin. Pathol. 2007; 127: 592–597.
15. Aly H. Postthyroidectomy hypocalcaemia. Egypt. J. Surg. 2008; 27: 41–47.
16. An C.M., Tang P.Z., Xu Z.G. et al. Role of parathyroid hormone measurement in prediction for symptomatic hypocalcaemia after total thyroidectomy. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010; 45: 217–221.
17. Arlt W., Fremerey C., Callies F. et al. Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur. J. Endocrinol. 2002; 146: 215–222.
18. Asari R., Koperek O., Kaczirek K. et al. Hypoparathyroidism after total thyroidectomy: A prospective study. Arch. Surg. 2008; 143: 132–137.
19. Barczynski M., Cichon S., Konturek A. Which criterion of intraoperative iPTH assay is the most accurate in prediction of true serum calcium levels after thyroid surgery? Langenbecks Arch. Surg. 2007; 392: 693–698.
20. Bellantone R., Lombardi C.P., Raffaelli M. et al. Is routine supplementation therapy (calcium and vitamin D) useful after total thy- roidectomy? Surgery. 2002; 132: 1109–1113.
21. Bergamaschi R., Becouarn G., Ronceray J., Arnaud J.P. Morbidity of thyroid surgery. Am. J. Surg. 1998; 176: 71–75.
22. Bergenfelz A., Jansson S., Kristofferson A. et al. Complications to thyroid surgery: results as reported in a database from a multicen- ter audit comprising 3660 patients. Langenbecks Arch. Surg. 2008; 393: 667–673.
23. Bhattacharyya N., Fried M. Assessment of the morbidity and com- plications of total thyroidectomy. Arch. Otolaryngol. Head Neck Surg. 2002; 128: 389–392.
24. Bilezikian J.P., Khan A., Potts J.T. Jr et al. Hypoparathyroidism in the Adult: Epidemiology, Diagnosis, Pathophysiology, Target- Organ Involvement, Treatment, and Challenges for Future Research. J. Bone and Mineral Research. 2011; 26: 2317–2337.
25. Biskobing D.M. Significance of elevated parathyroid hormone after parathyroidectomy. Endocr. Pract. 2010; 16: 112–117.
26. Bron L.P., O'Brien C.J. Total thyroidectomy for clinically benign disease of the thyroid gland. Br. J. Surg. 2004; 91: 569–574.
27. Cavicchi O., Piccin O., Caliceti U. et al. Transient hypoparathy- roidism following thyroidectomy: a prospective study and multi- variate analysis of 604 consecutive patients. Otolaryngol. Head Neck Surg. 2007; 137: 654–658.
28. Chapman D.B., French C.C., Leng X. et al. Parathyroid hormone early percent change: an individualized approach to predict postthy- roidectomy hypocalcemia. Am. J. Otolaryngol. 2012; 33: 216–220.
29. Cheah W.K., Arici C., Ituarte P.H. et al. Complications of neck dis- section for thyroid cancer. World. J. Surg. 2002; 26: 1013–1016.
30. Chia S.H., Weisman R.A., Tieu D. et al. Prospective Study of Perioperative Factors Predicting Hypocalcemia After Thyroid and Parathyroid Surgery. Arch. Otolaryngol. Head Neck Surg. 2006; 132: 41–45.
31. Chindavijak S. Prediction of Hypocalcemia in Postoperative Total Thyroidectomy using Single Measurement of Intra-operative Parathyroid Hormone Level. J. Med. Assoc. Thai. 2007; 90: 1167–1171.
32. Chow T.L., Chu W., Lim B.H., Kwok S.P.Y. Outcomes and complications of thyroid surgery: retrospective study. HKMJ. 2001; 7: 261–265.
33. Del Rio P., Sommaruga L., Bezer L. et al. Preoperative PTH as a marker of risk for post-thyroidectomy hypocalcemia. Minerva Endocrinol. 2010; 35: 47–52.
34. Doi Y., Yamashita H., Noguchi S. High prevalence of secondary hyperparathyroidism due to vitamin D insufficiency in Graves' disease. Clin. Calcium. 2005; 15: 68–70.
35. Erbil Y., Bozbora A., Ozbey N. et al. Predictive value of age and serum parathormone and vitamin D3 levels for postoperative hypocalcaemia after total thyroidectomy for nontoxic multinodu- lar goiter. Arch. Surg. 2007; 142: 1182–1187.
36. Erbil Y., Barbaros U., Temel B. et al. The impact of age, vitamin D(3) level, and incidental parathyroidectomy on postoperative hypocalcemia after total or near total thyroidectomy. Am. J. Surg. 2009; 197: 439–446.
37. Erbil Y., Ozbey N.C., Sari S. et al. Determinants of postoperative hypocalcemia in vitamin D-deficient Graves' patients after total thyroidectomy. Am. J. Surg. 2011; 201: 685–691.
38. Fahad Al:Dhahri S., Al:Ghonaim Y.A., Sulieman Terkawi A. Accuracy of postthyroidectomy parathyroid hormone and correct- ed calcium levels as early predictors of clinical hypocalcemia. J. Otolaryngol. Head Neck Surg. 2010; 39: 342–348.
39. Falk S.A., Birken E.A., Baran D.T. Temporary postthyroidectomy hypocalcemia. Arch. Otolaryngol. Head Neck Surg. 1998; 114: 168–174.
40. Fliser D., Stefanski A., Franek E. et al. No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects. Eur. J. Clin. Invest. 1997; 27: 629 –633.
41. Fong J., Khan A. Hypocalcemia. Updates in diagnosis and management for primary care. Can. Fam. Physician. 2012; 58: 158–162.
42. Graff A.T., Miller F.R., Roehm C.E., Prihoda T.J. Predicting hypocalcemia after total thyroidectomy: parathyroid hormone level vs. serial calcium levels. Ear. Nose Throat. J. 2010; 89: 462–465.
43. Grodski S., Serpell J. Evidence for the Role of Perioperative PTH Measurement after Total Thyroidectomy as a Predictor of Hypocalcemia. Wld J. Surg. 2008; 32: 1367–1373.
44. Harris V.W., De Beur S.J. Postoperative Hypoparathyroidism: Medical and Surgical Therapeutic Options. Thyroid. 2009; 19: 967–973.
45. Holick M.F. High Prevalence of Vitamin D Inadequacy and Implications for Health. Mayo Clin. Proc. 2006; 81: 353–373.
46. Holick M.F. Vitamin D Deficiency. N. Engl. J. Med. 2007; 357: 266–281.
47. Husein M., Hier M.P., Al:Abdulhadi K., Black M. Predicting Calcium Status Post Thyroidectomy with Early Calcium Levels. Otolaryngol. Head Neck Surg. 2002; 127: 289–293.
48. Jacques A., Page C., Justinien E. et al. Vitamin D deficiency contributes to post-thyroidectomy hypocalcemia. Endocr. Abstracts. 2010; 22: 772.
49. Kарromberger R., Ott J., Kober F. et al. Normal parathyroid hormone levels do not exclude permanent hypoparathyroidism after thyroidectomy. Thyroid. 2011; 21: 145–150.
50. Kara M., Tellioglu G., Krand O. et al. Predictors of hypocalcemia occurring after a total/near total thyroidectomy. Surg. Today. 2009; 39: 752–757.
51. Khan M.I., Waguespack S.G., Hu M.I. Medical management of postsurgical hypoparathyroidism. Endocr. Pract. 2011; 17: 18–25.
52. Kim J.H., Chung M.K., Son Y.:I. Reliable Early Prediction for Different Types of Post-Thyroidectomy Hypocalcemia. Clin. Exper. Otorhinolar. 2011; 4: 95–100.
53. Kirkby:Bott J., El:Khatib Z., Soudan B. et al. 25-hydroxy vitamin D deficiency causes parathyroid incidentalomas. Arch. Surg. 2010; 395: 474.
54. Kirkby:Bott J., Markogiannakis H., Skandarajah A. et al. Preoperative Vitamin D Deficiency Predicts Postoperative Hypocalcemia After Total Thyroidectomy. Wld. J. Surg. 2011; 35: 324–330.
55. Koutkia P., Lu Z., Chen T.C., Holick M.F. Treatment of vitamin D deficiency due to Crohn’s disease with tanning bed ultraviolet B radiation. Gastroenterology 2001; 121: 1485–1488.
56. Kovacevic B., Ignjatovic M., Cuk V. et al. Early prediction of symptomatic hypocalcemia after total thyroidectomy. Acta Chir. Belg. 2011; 111: 303–307.
57. Kurukahvecioglu O., Karamercan A., Akin M. et al. Potential benefit of oral calcium/vitamin D administration for prevention of symptomatic hypocalcemia after total thyroidectom. Endocr. Regul. 2007; 41: 35–39.
58. Leahu A., Carroni V., Biliotti G. Calcium level, a predictive factor of hypocalcemis following total thyroidectomy. Jurnalul de Chirurgie, Iasi. 2009; 5: 148–152.
59. Lindblom P., Westerdahl J., Bergenfelz A. Low parathyroid homrmone levels after thyroid surgery. Surgery. 2002; 131: 515–520.
60. Lombardi C.P., Raffaelli M., Princi P., Santini S. Early prediction of postthyroidectomy hypocalcemia by one single iPTH measure- ment. Surgery. 2004; 136: 1236–1241.
61. Luu Q., Andersen P.E., Adams J. et al. The predictive value of perioperative calcium levels after thyroid/parathyroid surgery. Head Neck. 2002; 24: 63–67.
62. Marx S.J. Hyperparathyroid and hypoparathyroid disorders. N. Engl. J. Med. 2000; 343: 1863–1875.
63. Miccoli P., Vitti P., Rago T. et al. Surgical treatment of Graves' disease: subtotal or total thyroidectomy? Surgery 1996; 120: 1020–1025.
64. Mishra A., Agarwal G., Agarwal A., Mishra S.K. Safety and efficacy of total thyroidectomy in hands of endocrine surgery trainees. Am. J. Surg. 1999; 178: 377–380.
65. Moore C., Lampe H., Agrawal S. Predictability of hypocalcemia using early postoperative serum calcium levels. J. Otolaryngol. 2001; 30: 266–270.
66. Nahas Z.S., Farrag T.Y., Lin F.R. et al. A safe and cost-effective short hospital stay protocol to identify patients at low risk for the development of significant hypocalcemia after total thyroidectomy. Laryngoscope. 2006; 116: 906–910.
67. Page C., Strunski V. Parathyroid risk in total thyroidectomy for bilateral, benign, multinodular goiter: Report of 351 surgical cases. J. Laryngol. Otol. 2007; 121: 237–241.
68. Pattou F., Combemale F., Fabre S. et al. Hypocalcaemia following thyroid surgery: incidence and prediction of outcome. Wld. J. Surg. 1998; 22: 718–724.
69. Payne R.J., Hier M.P., Tamilia M. Same-day discharge after total thyroidectomy: the value of 6-hour serum parathyroid hormone and calcium levels. Head Neck. 2005; 27: 1–7.
70. Payne R.J., Marc A.T. et al. Benefits Resulting from 1- and 6-hour Parathyroid Hormone and Calcium Levels After Thyroidectomy. Otolaryngology–Head and Neck Surg. 2005; 133: 386–390.
71. Pereira J.A., Jimeno J., Miquel J. et al. Nodal yield, morbidity, and recurrence after central neck dissection for papillary thyroid carcinoma. Surgery 2005; 138: 1095–1100.
72. Pietras S.M., Holick M.F. Refractory hypocalcemia following neartotal thyroidectomy in a patient with a prior Roux-en-Y gastric bypass. Obes. Surg. 2009; 19: 524–526.
73. Press D., Politz D., Lopez J., Norman J. The effect of vitamin D levels on postoperative calcium requirements, symptomatic hypocalcemia, and parathormone levels following parathyroidectomy for primary hyperparathyroidism. Surgery 2011; 150: 1061–1068.
74. Proczko:Markuszewska M., Kobiela J., Stefaniak T. et al. Postoperative PTH measurement as a predictor of hypocalcaemia after thyroidectomy. Acta. Chir. Belg. 2010; 110: 40–44.
75. Promberger R., Ott J., Kober F. et al. Normal parathyroid hormone levels do not exclude permanent hypoparathyroidism after thyroidectomy. Thyroid. 2011; 21: 145–150.
76. Qari F.A. Estimation of Ionized Calcium Levels after Thyroidectomy at King Abdul Aziz University Hospital (Jeddah). Kuwait Med. J. 2005; 37: 169–172.
77. Quiros R.M., Pesce C.E., Wilhelm S.M. et al. Intraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementa- tion. Am. J. Surg. 2005; 189: 306–309.
78. Richards M.L., Thompson G.B., Farley D.R., Grant C.S. Reoperative parathyroidectomy in 228 patients during the era of minimalaccess surgery and intraoperative parathyroid hormone monitoring. Am. J. Surg. 2008; 196: 937–943.
79. Roh J.L., Park C.I. Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy. Head Neck. 2006; 28: 990–997.
80. Roh J.L., Park J.Y., Park C.I. Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone. Ann. Surg. 2007; 245: 604–610.
81. Roh J.L., Park J.Y., Park C.I. Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differantiated papillary thyroid carcionoma undergo- ing thyroidecotmy plus central neck dissection. Cancer 2009; 115: 251–258.
82. Rosato L., Avenia N., Bernante P. et al. Complications of thyroid surgery: analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years. Wld. J. Surg. 2004; 28: 271–276.
83. Sam A.H., Dhillo W.S., Donaldson M. et al. Serum Parathyroid Hormone Is Not an Accurate Predictor of Postthyroidectomy Hypocalcemia in Vitamin D – Deficient Patients: A Pilot Study. Clinical Chemistry. 2011; 57: 1206–1207.
84. Sanabria A., Dominguez L.C., Vega V. et al. Routine postoperative administration of vitamin D and calcium after total thyroidectomy: a meta-analysis. Int. J. Surg. 2011; 9: 46–51.
85. Sands N., Young J., MacNamara E. et al. Preoperative parathyroid hormone levels as a predictor of postthyroidectomy hypocalcemia. Otolaryngol. Head Neck Surg. 2011; 144: 518–521.
86. Sasson A.R., Pingpank J.F. Jr, Wetherington R.W. et al. Incidental parathyroidectomy during thyroid surgery does not cause transient symptomatic hypocalcaemia. Arch. Otolaryngol. Head Neck Surg. 2001; 127: 304–308.
87. Scurry W.C. Jr, Beus Ki.S., Hollenbeak C.S., Stack B.C. Jr. Perioperative Parathyroid Hormone Assay for Diagnosis and Management of Postthyroidectomy Hypocalcemia. Laryngoscope 2005; 115: 1362–1366.
88. See A.C.H., Soo K.C. Hypocalcemia following thyroidectomy for thyrotoxicosis. Br. J. Surg. 1997; 84: 95–97.
89. Shoback D. Clinical practice: Hypoparathyroidism. New. Engl. J. Med. 2008; 359: 391–403.
90. Sitges:Serra A., Ruiz S., Girvent M. et al. Outcome of protracted hypoparathyroidism after total thyroidectomy. Br. J. Surg. 2010; 97: 1687–1695.
91. Sogutlu G., Cicim S.A., Olmez A. et al. Postoperative Hypoparathyroidism in Total Thyroidectomy: Incidence and Predictive Factors. Turk. Jem. 2007; 11: 16–19.
92. Tartaglia F., Giuliani A., Sgueglia M. et al. Randomized study on oral administration of calcitriol to prevent symptomatic hypocalcemia after total thyroidectomy. Am. J. Surg. 2005; 190: 424–429.
93. Thomusch O., Machens A., Sekulla C. et al. The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients. Surgery 2003; 133: 180–195.
94. Tredici P., Grosso Е., GiBelli B. et al. Identification of patients at high risk for hypocalcemia after total thyroidectomy. Acta Otorhinolaryng. Ital. 2010; 31: 144–148.
95. Wang T.S., Cayo A.K., Wilson S.D., Yen T.W. The value of postoperative parathyroid hormone levels in predicting the need for longterm vitamin D supplementation after total thyroidectomy. Ann. Surg. Oncol. 2011; 18: 777–781.
96. Wang T.S., Roman S.A., Sosa J.A. et al. Postoperative calcium supplementation in patients undergoing thyroidectomy. Curr. Opin. Oncol. 2012; 24: 22–28.
97. Warren F.M., Andersen P.E., Wax M.K., Cohen J.I. Perioperative levels in thyroid surgery: preliminary report. Laryngoscope 2004; 114: 689–693.
98. Wilson R.B., Erskine C., Crowe P.J. Hypomagnesemia and hypocalcaemia after thyroidectomy: prospective study. Wld. J. Surg. 2000; 24: 722–726.
99. Yamashita H., Murakami T., Noguchi S. et al. Postoperative Tetany in Graves Disease Important Role of Vitamin D Metabolites. Ann. Surg. 1999; 229: 237–245.
100. Youngwirth L., Benavidez J., Sippel R., Chen H. Parathyroid hormone deficiency after total thyroidectomy: incidence and time. J. Surg. Res. 2010; 163: 69–71.
101. Zarnegar R., Brunaud L., Clark O.H. Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinoma. Endocrin. Metab. Clin. N. Am. 2003; 32: 483–502.
102. Zuberi K.A., Urquhart A.C. Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomy. Laryngoscope 2010; 120: S1.
Рецензия
Для цитирования:
Kuznetsov N.S., Simakina O.V., Kim I.V. Предикторы послеоперационного гипопаратиреоза после тиреоидэктомии и методы его лечения. Клиническая и экспериментальная тиреоидология. 2012;8(2):20-30. https://doi.org/10.14341/ket20128220-30
For citation:
., ., . Predictors of postoperative hypoparathyroidism after thyroidectomy and methods of treatment. Clinical and experimental thyroidology. 2012;8(2):20-30. (In Russ.) https://doi.org/10.14341/ket20128220-30
Просмотров: 723
Контент доступен под лицензией Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Послать статью по эл. почте 
