Levothyroxine replacement therapy in patients with hypothyroidism, blood pressure and myocardial remodeling
https://doi.org/10.14341/ket20117141-44
Abstract
Our purpose was to investigate the short-term influence of thyroxin replacement therapy on arterial hypertension (AH) and heart remodeling in patients with primary hypothyroidism (PH). 52 patients with PH and AH received basic antihypertensive therapy unchanged during the period of study and individual l-thyroxin titration. All patients underwent echocardiography and daily blood pressure monitoring twice: in decompensation and after reaching euthyroid state in 3–4 months. Decrease in systolic blood pressure daytime by 5.6% (p<0.01), nighttime by 4.3% (p<0.05), left atrium volume by 12.8% (р<0.05), interventricular septum thickness by 5.8% (p<0.05), posterior wall thickness by 5.4% (p<0.05), end-diastolic dimension by 3.1% (p<0.05) and left ventricular mass index by8.1% (р<0.05) were observed in the patients with PH after reaching euthyroid state. Compensation of thyroid state in patients with PH and AH leads to decrease in systolic BP and improvement of echocardiographic left ventricular parameters.
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, , , , Levothyroxine replacement therapy in patients with hypothyroidism, blood pressure and myocardial remodeling. Clinical and experimental thyroidology. 2011;7(1):41-44. (In Russ.) https://doi.org/10.14341/ket20117141-44
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