The clinical tomographic interconnection in diplopia of patients with Graves' orbitopathy
https://doi.org/10.14341/ket20128140-45
Abstract
There was investigated the relationship between the clinical features of the diplopia in patients with the Graves’ orbitopathy and the specific signs of the orbit obtained by the multi-slice CT scanning in the study. The results of the study could improve the diagnosis of the Graves’ orbitopathy and evaluate the effectiveness of the treatment. Eighty five patients (170 eyes) of ages from 24 till 73 years were included in the study. The ophthalmological examination and multi-slice CT scanning of the orbit were performed in all cases. The activity and severity of the Graves’ orbitopathy were assessed according to EUGOGO clinical activity score. The severity of the diplopia was graduated subjectively using the clinical assessment technique described previously (Nagy E.V. et al., 2000). It was found that the severity of the diplopia was significanty higher during the active phase of the disease and correlated with the muscular index (p = 0,0320, r = 0,294589), the extraocular muscle enlargement (p = 0,0118) and the retrobulbar tissue density (p = 0,0335, r = 0,336906). The diplopia was associated with enhancement of the retrobulbar tissue density and the extraocular muscle density in the inactive phase of the disease. There wasn’t the correlation between the severity of the diplopia and the extraocular muscle enlargement in the inactive phase of the disease. There was established the relationship between the clinical features of the diplopia and the signs obtained by the multi-slice CT scanning of the orbit. These results are extremely important for the detection the causes of the diplopia, the treatment selection and the estimation the prognosis.
About the Authors
A Chepurinaaspirant otdeleniya terapii s gruppoy patologii metabolizma i ozhireniya FGBU Endokrinologicheskiy nauchnyy tsentr
N Sviridenko
doktor med. nauk, glavnyy nauchnyy sotrudnik otdeleniya terapii s gruppoy patologii metabolizma i ozhireniya FGBU ENTs
O Remizov
doktor med. nauk, zaveduyushchiy otdeleniem rentgenodiagnostiki i rentgenovskoy komp'yuternoy tomografii FGBU ENTs
I Belovalova
kand. med. nauk, zam. direktora FGBU ENTs
M Sheremeta
kand. med. nauk, starshiy nauchnyy sotrudnik otdeleniya terapii s gruppoy patologii metabolizma i ozhireniya FGBU ENTs
N Goncharov
doktor med. nauk, professor, zaveduyushchiy laboratoriey gormonal'nogo analiza FGBU ENTs
S Prokofiev
kand. med. nauk, zaveduyushchiy laboratoriey genetiki i klinicheskoy immunologii FGBU ENTs
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, , , , , , The clinical tomographic interconnection in diplopia of patients with Graves' orbitopathy. Clinical and experimental thyroidology. 2012;8(1):40-45. (In Russ.) https://doi.org/10.14341/ket20128140-45
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