Thyroid dysfunction in infertile women
https://doi.org/10.14341/ket20117444-50
Abstract
Objective. To study the rate and structure of thyroid diseases in infertile women and to asses their reproductive system depending upon the thyroid pathology. Subjects and methods. The study was based on the results of screening of T status of 496 women with infertility (main group) and 80 fertile women (control group). Traditional methods of diagnosis of infertility were used along with special methods of investigation including assessment of function and structure of T (TTH, fT4, fT3, AT-TPO, AT-rTTH, ultrasound examination of T, thin-niddle aspirational biopsy, scintigraphy of T). A complex evaluation of the reproductive system status in infertile women was done depending on the type of T pathology. Results. Infertile women were found to suffer from thyroid dysfunction 3.8 times as more often as fertile ones (48% and 12.5%, p <0.05). Its structure included mainly AT-TPO carrier phenomenon in combination with ultrasound markers of thyroid autoimmunity (24%), hypothyroidism following thyroid autoimmunity (9.4%) demonstrating itself as clinical (0.8%), subclinical (8.6%), and euthyroid (7.8%) goiters. The portion of women with infertility and hyperthyroidism was small (0.6%). An association of thyroid autoimmunity with idiopathic infertility, endometriosis, endocrine infertility was found. Conclusion. It is necessary to perform a screening assessment of the function and structure of T in infertile women within diagnostic search for the reasons of infertility and in-time correction of the revealed thyroid dysfunction.
About the Author
S Perminovadoktor med. nauk, vedushchiy nauchnyy sotrudnik 1#go ginekologicheskogo otdeleniya Nauchnogo tsentra akusherstva, ginekologii i perinatologii im. akademika V.I. Kulakova Minzdravsotsrazvitiya Rossii
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For citations:
Thyroid dysfunction in infertile women. Clinical and experimental thyroidology. 2011;7(4):44-50. (In Russ.) https://doi.org/10.14341/ket20117444-50
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