Outpatient treatment of Graves disease patients with fixed I 131activity
https://doi.org/10.14341/ket20139138-41
Abstract
Results of treatment of 32 Graves disease patients with fixed activity of I131 in an outpatient mode were analyzed. 131 acitivty was 15 mCi (555 MBq). Mean age of patients was 48.5 years (20–70 years). Mean thyroid volume – 23 ± 13.9 ml. In 5 (15.6%) patients relapse of thyrotoxicosis was observed. Stable euthyroid state was revealed in 1 (3.1%) patient (follow up period 18 months). In 26 (81.3%) patients hypothyroidism occurred after the treatment. Total effectiveness of the treatment was 84.4%. In a group of patients with thyroid volume less than 50 ml total effec tiveness of the treatment was 93.1%.
About the Authors
M Isheyskayavrach-endokrinolog, Natsional'nyy medikokhirurgicheskiy Tsentr im. N.I. Pirogova
I Sleptsov
kand. med. nauk, khirurgendokrinolog, zamestitel' direktora po meditsinskoy chasti, Natsio nal'nyy medikokhirurgicheskiy Tsentr im. N.I. Pirogova
A Semenov
kand. med. nauk, khirurgendokri nolog, Natsional'nyy medikokhirurgicheskiy Tsentr im. N.I. Pirogova
R Chernikov
kand. med. nauk, zaveduyushchiy otdeleniem endokrinnoy khirurgii, Natsional'nyy mediko-khirurgicheskiy Tsentr im. N.I. Pirogova
I Chinchuk
kand. med. nauk, khirurg-endokrinolog, Natsional'nyy mediko-khirurgicheskiy Tsentr im. N.I. Pirogova
A Uspenskaya
khirurg-endokrinolog, Natsional'nyy mediko-khirurgicheskiy Tsentr im. N.I. Pirogova
V Makaryin
kand. med. nauk, khirurg-endokrinolog, Natsional'nyy mediko-khirurgicheskiy tsentr im. N.I. Pirogova
Yu Fedotov
doktor med. nauk, direktor Natsional'nogo mediko-khirurgicheskogo tsentra im. N.I. Pirogova
A Pashko
kand. med. nauk, kafedra operativnoy khirurgii i topograficheskoy anatomii Sankt-Peterburgskogo gosudarstvennogo pediatricheskogo meditsinskogo universiteta
A Bubnov
doktor med. nauk, professor, kafedra operativnoy khirurgii i topograficheskoy anatomii Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I.I. Mechnikova
References
1. Weetman A.P., Pickerill A.P., Watson P. et al. Treatment of Graves' disease with the blockreplace regimen of antithyroid drugs. The effect of treatment duration and immunogenetic susceptibility on relapse. QJM 1994; 87: 337–341.
2. Maugendre D., Gatel A., Campion L. et al. Antithyroid drugs and Graves' disease – prospective randomised assessment of longterm treatment. Clin. Endocrinol. 1999; 50: 127–132.
3. Rittmaster R.S., Abbott E.С., Douglas R. et al. Effect of methima zole, with or without Lthyroxine, on remission rates in Graves’ disease. J. Clin. Endocrinol. Metab. 1998; 83: 814–818.
4. Bahn R.S., Burch H.B., Cooper D.S. et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the american thyroid association and american association of clinical endocrinologists. Endocr. Practice. 2011; 17 (3): 456–520.
5. Jarlov A.E., Hegedus L., Kristensen L.O. et al. Is calculation of the dose in radioiodine therapy of hyperthyroidism worth while? Clin. Endocrinol. 1991; 43: 325–329.
6. Alexander E.K., Larsen P.R. High dose 131I therapy for the treat ment of hyperthyroidism caused by Graves' disease. J. Clin. Endocrinol. Metab. 2002; 87; 1073–1077.
7. Peters H., Fischer C., Bogner U. et al. Radioiodine therapy of Graves’ hyperthyroidism: standard vs. calculated 131 iodine activ ity. Results from a prospective, randomized, multicentre study. Eur. J. Clin. Invest. 1995; 25: 186–193.
8. Leslie W.D., Ward L., Salamon E.A. et al. A randomized compari son of radioiodine doses in Graves’ hyperthyroidism. J. Clin. Endocrinol. Metab. 2003; 88: 978–983.
9. Sisson J.C., Avram A.M., Rubello D. et al. Radioiodine treatment of hyperthyroidism: fixed or calculated doses; intelligent design or science? Eur. J. Nucl. Med. Mol. Imaging. 2007; 34: 1129–1130.
10. van Isselt J.W., de Klerk J.M., Lips C.J. Radioiodine treatment of hyperthyroidism: fixed or calculated doses; intelligent design or science? Eur. J. Nucl. Med. Mol. Imaging. 2007; 34: 1883–1884.
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