It has been found during the research that the changes of Th1 and Th2 marker cytokine content in Graves Disease are dynamic and are directly correlated not only with the severity of autoimmune thyrotoxicosis, but also with the method of treatment used and duration of Thiamazole therapy. The beginning of autoimmune thyrotoxicosis shows the largest amounts of both pro-inflammatory (IL-1a, IL-8, IFN-γ) and anti-inflammatory (IL-10) cytokines which are significantly reduced during Thiamazole therapy, with the exception of the cases of severe disease course. Thyroid resection does not result in immunologic remission either, which is confirmed by persisting high serum levels of IL-1a, IL-8, IFN-γ, IL-10 and TSH antibodies in the severe GBD group. Among the unfavorable prognostic factors for recurrent disease are high serum levels of TSH antibodies, IL-1a and IFN-γ during pre-surgery period.

He aim of the study was to investigate the linkage of diffuse euthyroid goiter (DEG) in Moscow population to polymorphisms of TSHR (rs 3783949, alleles - A/C), NIS (rs 7250346, alleles - C/G), DUOX1 (rs2467825, alleles - A/G), DUOX2 (rs7171366, alleles - G/T), TPO (rs17091737, alleles - G/T). To approach the problem, the prevalence of these polymorphisms was estimated in two age- and sex-matched groups: in DEG patients (n = 100) and in the control group (n = 100). High risk DEG formation was found in patients with the following genotypes: GG and CG of NIS, OR = 2.07 (95% CI 1.18-3.64); AG and AA of DUOX1, OR = 1.92 (95% CI 1.08-3.39); TT of TPO, OR = 2.09 (95% CI 1.19-3.7). Low risk DEG formation was found in patients with the following genotypes: CC of NIS, OR = 0.48(95% CI 0.27-0.85); GG of DUOX1, OR = 0.52 (95% CI 0.29-0.92); GG and TG of TPO, OR = 0.48 (95% CI 0.27-0.83). No significant difference between genotypes prevalence of DUOX2 and TSHR in two comparable groups was observed. Our results provide the first confirmation of linkage of diffuse euthyroid goiter to polymorphisms of NIS, DUOX1 and TPO in Moscow population.

The article is presents the results of estimation efficiency of various schemes pathogenetic glucocorticoids treatment of autoimmune ophthalmopathy. Research of clinical parameters dynamics including subjective and objective attributes, proptosis, dynamics of the soluble form of intercellular molecule adhesion-1 levels was made before treatment and at the end of research (in 6 month follow up after complete course of pathogenetic treatment). The study has demonstrated that combination of glucocorticoids pulse-therapy and mean volume plasmapheresis is the most effective pathogenetic method of autoimmune ophthalmopathy treatment; absence of advantages of the used schemes of treatment for reduction proptosis. Advantages of use of the combined therapy are marked in comparison with monotherapy by glucocorticoids at estimation of subjective attributes.

The purpose of research was studying of a condition circadian rhythms and parameters of a daily structure according to 24-hour monitoring blood pressure at sick with the verified diagnosis of autoimmune thyroidite in a phase of subclinical hypothyroidism. 23 patients (22 women and 1 man) in the age of from 18 till 58 years are surveyed. The control group was made by practically healthy 25 persons without pathology of a thyroid gland and normal values of blood pressure of similar age. It is revealed, that at patients with autoimmune thyroidite in a phase of subclinical hypothyroidism higher levels of systolic blood pressure and diastolic blood pressure in day time and night hours, also infringement circadian a rhythm of systolic blood pressure “non-dipper” at 39,2% of patients are defined. It is received, that according to 24-hour monitoring blood pressure these patients have features of dynamics of the diastolic blood pressure, described increase of diastolic blood pressure in the afternoon and excessive decrease at night in 30,4% of cases.